Welcome to the Study, Rebecca!

Nighttime NAD+ Complete Sleep Trial

Principal Investigator: Renue Research Team
Protocol Number: RR-NACS-2026-001
Date: March 2026

1. Purpose of the Study

This study aims to evaluate the effects of Nighttime NAD+ Complete supplementation on sleep quality, sleep onset latency, and next-day energy levels in healthy adults. The study uses consumer-grade wearable data (Oura Ring) combined with participant self-reports to measure outcomes over a defined supplementation period.

2. What Participation Involves

If you agree to participate, you will be asked to:

• Complete a 7-day baseline period where you track your normal sleep patterns without supplementation using your Oura Ring and daily self-reports.
• Take Nighttime NAD+ Complete as directed for a 21-day supplementation period, continuing to track sleep data and complete daily self-reports.
• Export and submit your Oura Ring data at designated intervals.
• Complete brief daily logs (~2 minutes) and weekly check-in surveys (~5 minutes).
• Report any adverse events or unusual experiences promptly.

Total study duration is approximately 28 days (7-day baseline + 21-day supplementation).

3. Potential Risks

Nighttime NAD+ Complete is a dietary supplement. While generally well-tolerated, possible side effects may include:

• Mild gastrointestinal discomfort (e.g., nausea, bloating)
• Headache
• Vivid dreams or changes in sleep patterns during the adjustment period
• Skin flushing (rare, typically mild and transient)

If you experience any persistent or concerning symptoms, discontinue use and contact the research team immediately.

4. Voluntary Participation

Your participation in this study is entirely voluntary. You may withdraw at any time, for any reason, without penalty. Withdrawal will not affect your relationship with Renue by Science or your access to any products or services. If you choose to withdraw, any data collected up to that point may still be used in anonymized, aggregate analyses unless you specifically request its removal.

5. Data and Privacy

All data collected during this study will be handled in accordance with applicable privacy laws. Your personal information will be:

• Stored securely with encryption at rest and in transit
• Identified only by a participant code in research datasets
• Never sold to third parties
• Used solely for the purposes of this study and related research publications
• Retained for a minimum of 3 years following study completion for verification purposes

Oura Ring data you export and submit will be linked to your participant code, not your name or email address, in all research records.

6. Compensation

As a participant, you will receive:

• A complimentary supply of Nighttime NAD+ Complete for the duration of the study
• Early access to study results and personalized sleep insights from your data
• A 30% discount code for future Renue by Science purchases upon study completion

Compensation is contingent upon completing the full 28-day study protocol. Partial completion may qualify for partial compensation at the research team's discretion.

7. Reporting Adverse Events

If you experience any unexpected or adverse health effects during the study, please report them immediately through the study portal's "Report an Issue" feature or by emailing the research team directly. All adverse events will be reviewed within 24 hours and appropriate guidance will be provided.

8. Contact Information

If you have questions about this study, your rights as a participant, or wish to report a concern, please contact:

• Research Team: research@renuebyscience.com
• Study Portal Support: Available via the Support link in your dashboard